Aix Marseille Université, CNRS, INSERM, France
Dr. Narni-Mancinelli graduated in Biological Sciences from the University of Nice Sophia Antipolis. In 2008, she obtained a PhD in Immunology, Pharmacology, Molecular and Cellular Biology. During her doctoral studies, she investigated the molecular mechanisms of CD8+ T cell memory to ensure protective immunity against intracellular pathogens. She moved to the Center of Immunology in Marseille Luminy as a postdoctoral fellow and joined the team of Pr Vivier where she developed the NKp46iCre/+ mouse model allowing conditional deletion of genes specifically in NKp46+ cells. She also characterized the regulatory role of NK cells in adaptive immunity. For the past 10 years, she has led a group in the Pr Vivier lab that has been working on transcriptome profiling of tissue and blood NK cells in the steady state and in cancer. Her team has been involved in the discovery of a novel ligand for the natural cytotoxic activation receptor NKp46 expressed by NK cells and has demonstrated its role in the control of invasive bacterial infections. Dr. Narni-Mancinelli is also involved in translating the laboratory's basic research discoveries into clinical applications through the development of innovative therapeutic monoclonal antibodies, such as NK cell engagers. She is now leading the development of pan-genomic CIRSPR screens aimed at uncovering the molecular mechanisms that regulate tumor cell recognition and killing by NK cells. Dr. Narni-Mancinelli is a recipient of the French National Academy of Medicine and a member of the Scientific Committee of Canceropole PACA. She is the author of 42 publications (h-index: 23, > 3000 citations) and co-inventor of 5 patents.